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Revisiting STAT3 signalling in cancer: Associated Data Supplementary Materials mmc8. The urgent need to recover MHC class I in cancers for effective immunotherapy. One out of two representative experiments is shown. Principal component analysis was performed on 3894 out of 6672 proteins quantified in all 19 samples. Upon differential analysis of tumor versus healthy tissues we defined a tumor-modulated signature of 987 proteins Figure 2 B; Table S5.

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The data were analyzed using Proteome Discoverer version 2. The implicated canonical cancer signatures apparently do not suffice to give rise to transmissible cancers in humans. Proteomic analysis of human cataract aqueous humour: Results ERBB-Specific Vulnerability of DFTD Identified by Pharmacological Screening To address the inherent limitations of working with non-model organisms such as the Tasmanian devil, we characterized cell lines and primary biopsies Table S1 through an integrative and unbiased systems-biology approach consisting of pharmacological screens, transcriptomics, proteomics, and epigenomics. In addition, we performed a thermal shift assay and observed a dose-dependent decrease in the denaturation temperature of recombinant STAT3, indicative of covalent protein-ligand binding interaction de Araujo et al.

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Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Schwann cells and repair of the peripheral nervous. Otsu, with three classes thresholding, pixels in the middle intensity class were assigned as background and objects touching the image boundary were discarded. B Hierarchical clustering of the 987 differentially modulated proteins between tumor and healthy biopsies. Genomic restructuring in the Tasmanian devil facial tumour:

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